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    Chapter 29 of 165 · Endocrine & Metabolic

    Dry Dwayne — Diabetes Insipidus

    Liters of pale urine, Na⁺ ↑, specific gravity < 1.005

    Dry Dwayne, the MnemoNurse character for Diabetes Insipidus

    Dwayne cannot hold on to water. It runs straight through him — pale as tap water, liter after liter — while the salt left behind concentrates in his blood.

    Dwayne loses ADH after a head injury and cannot concentrate urine. He puts out liters of dilute urine, gets desperately thirsty and his sodium climbs. Replace fluids, give desmopressin, and watch for the opposite problem — water intoxication.

    Read Dry Dwayne's full story →

    The story arc

    1. The setup

      A traumatic brain injury bruises the pituitary; ADH output falls within days.

    2. The turn

      He drinks constantly and still feels parched. Urine output hits 400 mL/hr and looks like water.

    3. The crisis

      Sodium 158, blood pressure 88/54, heart rate 122, and he becomes too drowsy to keep drinking.

    4. The save

      Hypotonic fluids replace the deficit and desmopressin restores ADH — then output, weight and sodium are watched for over-correction.

    NCLEX study section — Diabetes Insipidus

    What this chapter is testing: the recognition cues, the numbers and the priority action.