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    Chapter 71 of 165 · Safety & Infection Control

    Spore Sean — Clostridioides difficile & Isolation Precautions

    Watery diarrhea after antibiotics — soap and water, not hand sanitizer

    Spore Sean, the MnemoNurse character for Clostridioides difficile & Isolation Precautions

    Sean has had seven watery, foul-smelling stools since yesterday, just two weeks after finishing antibiotics for pneumonia. His abdomen is tender and distended.

    Sean finished a course of broad-spectrum antibiotics for a respiratory infection, which wiped out his normal gut flora and let C. difficile spores take over. C. diff produces toxins that cause profuse, foul-smelling watery diarrhea and can progress to life-threatening colitis. Because C. diff forms spores, alcohol-based hand sanitizer does NOT kill it — only soap-and-water hand hygiene physically removes the spores, and contact precautions with a dedicated, dedicated-cleaned room are required.

    Read Spore Sean's full story →

    The story arc

    1. The setup

      Sean's ten-day course of broad-spectrum antibiotics for pneumonia disrupts the normal balance of bacteria in his colon.

    2. The turn

      A few days after finishing antibiotics, Sean develops loose stools that he brushes off as a stomach bug.

    3. The crisis

      He now has more than six watery, foul-smelling stools a day, abdominal cramping and distention, and a low-grade fever. Stool toxin testing confirms C. difficile.

    4. The save

      Sean is placed in a private room on contact precautions with a dedicated stethoscope and equipment, everyone washes with soap and water before and after entering, and oral vancomycin or fidaxomicin is started while the offending antibiotic is stopped if possible.

    NCLEX study section — Clostridioides difficile & Isolation Precautions

    What this chapter is testing: the recognition cues, the numbers and the priority action.